METHADONE ENANTIOMERS NO FURTHER A MYSTERY

[sixty one] Like quite a few other cardiotoxic drugs, methadone blocks the hERG K+ channel. The 2 enantiomers of methadone inhibit hERG channels with different potency. Dextromethadone, and that is much less potent being an opioid, is more potent at blocking the hERG channel with an IC50 of ~twelve μM. Levomethadone has a lower affinity, with an I